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Royal Society of Chemistry

Toxicity of tryptophan manganese (i) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae

Overview of attention for article published in RSC Medicinal Chemistry, January 2017
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Title
Toxicity of tryptophan manganese (i) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae
Published in
RSC Medicinal Chemistry, January 2017
DOI 10.1039/c6md00603e
Pubmed ID
Authors

Jonathan S. Ward, Rebecca Morgan, Jason M. Lynam, Ian J. S. Fairlamb, James W. B. Moir

Abstract

The potential for carbon monoxide-releasing molecules (CO-RMs) as antimicrobials represents an exciting prospective in the fight against antibiotic resistance. Trypto-CORM, a tryptophan-containing manganese(i) carbonyl, is toxic against E. coli following photo-activation. Here, we demonstrate that Trypto-CORM is toxic against Neisseria gonorrhoeae in the absence of photoactivation. Trypto-CORM toxicity was reversed by the high CO affinity globin leg-haemoglobin (Leg-Hb), indicating that the toxicity is due to CO release. Release of CO from Trypto-CORM in the dark was also detected with Leg-Hb (but not myoglobin) in vitro. N. gonorrhoeae is more sensitive to CO-based toxicity than other model bacterial pathogens, and may serve as a viable candidate for antimicrobial therapy using CO-RMs.

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Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 18%
Researcher 7 16%
Student > Ph. D. Student 7 16%
Professor 4 9%
Student > Bachelor 3 7%
Other 9 20%
Unknown 7 16%
Readers by discipline Count As %
Chemistry 20 44%
Medicine and Dentistry 5 11%
Biochemistry, Genetics and Molecular Biology 4 9%
Agricultural and Biological Sciences 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 4 9%
Unknown 8 18%