Title |
Toxicity of tryptophan manganese (i) carbonyl (Trypto-CORM), against Neisseria gonorrhoeae
|
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Published in |
RSC Medicinal Chemistry, January 2017
|
DOI | 10.1039/c6md00603e |
Pubmed ID | |
Authors |
Jonathan S. Ward, Rebecca Morgan, Jason M. Lynam, Ian J. S. Fairlamb, James W. B. Moir |
Abstract |
The potential for carbon monoxide-releasing molecules (CO-RMs) as antimicrobials represents an exciting prospective in the fight against antibiotic resistance. Trypto-CORM, a tryptophan-containing manganese(i) carbonyl, is toxic against E. coli following photo-activation. Here, we demonstrate that Trypto-CORM is toxic against Neisseria gonorrhoeae in the absence of photoactivation. Trypto-CORM toxicity was reversed by the high CO affinity globin leg-haemoglobin (Leg-Hb), indicating that the toxicity is due to CO release. Release of CO from Trypto-CORM in the dark was also detected with Leg-Hb (but not myoglobin) in vitro. N. gonorrhoeae is more sensitive to CO-based toxicity than other model bacterial pathogens, and may serve as a viable candidate for antimicrobial therapy using CO-RMs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 18% |
Researcher | 7 | 16% |
Student > Ph. D. Student | 7 | 16% |
Professor | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 9 | 20% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 20 | 44% |
Medicine and Dentistry | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Agricultural and Biological Sciences | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 9% |
Unknown | 8 | 18% |