| Title |
Anti-tumour active gold( i ), palladium( ii ) and ruthenium( ii ) complexes with thio- and selenoureato ligands: a comparative study
|
|---|---|
| Published in |
Dalton Transactions: An International Journal of Inorganic Chemistry, January 2018
|
| DOI | 10.1039/c7dt04180b |
| Pubmed ID | |
| Authors |
Anja Molter, Stefanie Kathrein, Brigitte Kircher, Fabian Mohr |
| Abstract |
We report the results of a comparative study of the biological activity of a series of gold(i), palladium(ii) and ruthenium(ii) complexes containing deprotonated thio- and selenoureato ligands. A library of compounds was prepared and characterised by spectroscopic methods and the solid-state structures of several derivatives were determined by single crystal X-ray diffraction. The in vitro activity of these compounds was evaluated in mammary and ovarian carcinoma, acute lymphatic and acute and chronic myeloid leukemia cell lines. At lower concentrations Ru- and Pd-containing compounds displayed stronger anti-cancer effects than the gold compounds. In all cases, the selenium derivatives proved to be more active than the corresponding sulfur compounds. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 27% |
| Student > Bachelor | 3 | 10% |
| Student > Doctoral Student | 2 | 7% |
| Other | 2 | 7% |
| Student > Master | 2 | 7% |
| Other | 5 | 17% |
| Unknown | 8 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 13 | 43% |
| Agricultural and Biological Sciences | 1 | 3% |
| Neuroscience | 1 | 3% |
| Medicine and Dentistry | 1 | 3% |
| Unknown | 14 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2018.
All research outputs
#23,109,385
of 25,756,911 outputs
Outputs from Dalton Transactions: An International Journal of Inorganic Chemistry
#12,535
of 21,221 outputs
Outputs of similar age
#392,187
of 452,073 outputs
Outputs of similar age from Dalton Transactions: An International Journal of Inorganic Chemistry
#853
of 1,567 outputs
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So far Altmetric has tracked 21,221 research outputs from this source. They receive a mean Attention Score of 1.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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